Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.46 |
| ▸ | ACACB | O00763 | 7/20 | 0.42 |
| ▸ | FLT3 | P36888 | 3/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.40 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4723183 | 0.92 | GPR119 (0.46) | GPR119ACACBFLT3CDK2CDK6 | |
| SCHEMBL391312 | 0.88 | GPR119 (0.59) | GPR119 | |
| SCHEMBL4723272 | 0.85 | GPR119 (0.46) | GPR119ACACBFLT3CDK2CDK6 | |
| SCHEMBL4723387 | 0.85 | GPR119 (0.49) | GPR119ACACBFLT3CDK2CDK6 | |
| SCHEMBL4722319 | 0.84 | GPR119 (0.43) | GPR119ACACBFLT3CDK2CDK6 | |
| SCHEMBL4721899 | 0.84 | GPR119 (0.46) | GPR119ACACBFLT3CDK2CDK6 | |
| SCHEMBL4722464 | 0.83 | GPR119 (0.60) | GPR119 | |
| SCHEMBL4721907 | 0.83 | GPR119 (0.47) | GPR119ACACBFLT3CDK2CDK6 | |
| SCHEMBL4720958 | 0.83 | GPR119 (0.46) | GPR119ACACBFLT3CDK2CDK6 | |
| SCHEMBL4721011 | 0.83 | FLT3 (0.49) | GPR119ACACBFLT3CDK2CDK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756084-B1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARM INC (US) | 2008-11-26 | — | — | EP | claimed |