Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 3/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.40 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.40 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | ACACB | O00763 | 2/20 | 0.39 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.39 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL387108 | 0.89 | GPR119 (0.55) | GPR119CYP1A2MAPTCYP2C19ERBB2 | |
| SCHEMBL4723183 | 0.85 | GPR119 (0.46) | GPR119FLT3CDK2CDK6ACACB | |
| SCHEMBL4723224 | 0.84 | GPR119 (0.46) | GPR119FLT3CDK2CDK6ACACB | |
| SCHEMBL4721011 | 0.83 | FLT3 (0.49) | GPR119FLT3CDK2CDK6ACACB | |
| SCHEMBL4723272 | 0.82 | GPR119 (0.46) | GPR119CYP1A2FLT3CDK2CDK6 | |
| SCHEMBL4723387 | 0.81 | GPR119 (0.49) | GPR119FLT3CDK2CDK6ACACB | |
| SCHEMBL4721899 | 0.81 | GPR119 (0.46) | GPR119FLT3CDK2CDK6ACACB | |
| SCHEMBL4722061 | 0.80 | GPR119 (0.51) | GPR119FLT3CDK2CDK6ACACB | |
| SCHEMBL4722464 | 0.80 | GPR119 (0.60) | GPR119 | |
| SCHEMBL4720958 | 0.79 | GPR119 (0.46) | GPR119FLT3CDK2CDK6ACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756084-B1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARM INC (US) | 2008-11-26 | — | — | EP | claimed |