Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.36 |
| ▸ | CTSD | P07339 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 6/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 7/20 | 0.33 |
| ▸ | LMNA | P02545 | 4/20 | 0.33 |
| ▸ | GAA | P10253 | 4/20 | 0.33 |
| ▸ | ATM | Q13315 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11065415 | 0.77 | TDP1 (0.44) | ALDH1A1TDP1HSD17B10CTSDTSHR | |
| SCHEMBL3396164 | 0.74 | TDP1 (0.37) | ALDH1A1TDP1HSD17B10CTSDTSHR | |
| SCHEMBL863709 | 0.72 | ALDH1A1 (0.50) | ALDH1A1TDP1HSD17B10CTSDTSHR | |
| SCHEMBL34463716 | 0.71 | IDO1 (0.42) | ALDH1A1TDP1HSD17B10CTSDTSHR | |
| SCHEMBL4654107 | 0.71 | ALDH1A1 (0.39) | ALDH1A1TDP1HSD17B10CTSDTSHR | |
| SCHEMBL2255542 | 0.71 | TDP1 (0.48) | ALDH1A1TDP1HSD17B10CTSDTSHR | |
| SCHEMBL943520 | 0.70 | MAPT (0.51) | ALDH1A1HSD17B10TSHRMAPTLMNA | |
| Bromide SCHEMBL30083679 | 0.69 | ALDH1A1 (0.47) | ALDH1A1TDP1HSD17B10CTSDTSHR | |
| SCHEMBL3483559 | 0.68 | TDP1 (0.40) | ALDH1A1TDP1HSD17B10CTSDTSHR | |
| SCHEMBL10697600 | 0.68 | TDP1 (0.44) | ALDH1A1TDP1HSD17B10TSHRALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963320-A1 | PYRROLOPYRIDINE KINASE INHIBITING COMPOUNDS | OSI Pharmaceuticals, Inc. (US) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007067537-A1 | PYRROLOPYRIDINE KINASE INHIBITING COMPOUNDS | OSI PHARMACEUTICALS, INC. (US) | 2007-06-14 | — | — | WO | disclosed |