Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADK | P55263 | 7/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | PLAU | P00749 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 3/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 3/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3581653 | 0.91 | ADK (0.38) | ADKGRM5ABL1PIK3CDPIK3CA | |
| SCHEMBL27649219 | 0.88 | LCK (0.39) | ADKGRM5ABL1FFAR1ALOX5 | |
| SCHEMBL5302989 | 0.86 | ABL1 (0.45) | ADKGRM5ABL1CA12CA1 | |
| SCHEMBL28758771 | 0.86 | TEK (0.44) | GRM5ABL1FFAR1KDRPTGDR2 | |
| SCHEMBL27672591 | 0.85 | LCK (0.42) | GRM5PLAUFFAR1ALOX5KDR | |
| SCHEMBL28761800 | 0.84 | ALOX5 (0.35) | ADKGRM5ABL1ALOX5 | |
| SCHEMBL27669462 | 0.84 | ADK (0.39) | ADK | |
| SCHEMBL5250424 | 0.81 | KDR (0.38) | ADKKDR | |
| SCHEMBL27669464 | 0.81 | ADK (0.33) | ADKGRM5ABL1PIK3CDPIK3CA | |
| SCHEMBL5250427 | 0.80 | NPC1 (0.37) | ADKKDRRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1737462-B1 | PYRIMIDINES WITH TIE2 (TEK) ACTIVITY | ASTRAZENECA AB (SE) | 2008-07-30 | — | — | EP | claimed |
| CN-1917880-A | Pyrimidines with tie2 (tek) activity | ASTRAZENECA AB (SE) | 2007-02-21 | — | — | CN | disclosed |