Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.35 |
| ▸ | ADK | P55263 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5250424 | 0.86 | KDR (0.38) | NPC1RAB9ASMN1; SMN2KDM4EMEN1 | |
| SCHEMBL3581653 | 0.81 | ADK (0.38) | KDRADKRET | |
| SCHEMBL4721937 | 0.80 | ADK (0.37) | KDRADKRET | |
| SCHEMBL4719226 | 0.75 | KDR (0.58) | NPC1RAB9ASMN1; SMN2MEN1LMNA | |
| SCHEMBL4718135 | 0.75 | ADK (0.48) | ADKRET | |
| SCHEMBL13499920 | 0.74 | CYP1A2 (0.49) | SMN1; SMN2KDM4EMAPTKMT2AKDR | |
| SCHEMBL4717817 | 0.73 | RAB9A (0.45) | NPC1RAB9ASMN1; SMN2KDM4EMEN1 | |
| SCHEMBL4719248 | 0.71 | PTPN11 (0.50) | NPC1RAB9ASMN1; SMN2MEN1MAPT | |
| SCHEMBL5251355 | 0.71 | KDR (0.54) | NPC1RAB9AMEN1LMNAMAPT | |
| SCHEMBL5302989 | 0.70 | ABL1 (0.45) | KDRADKHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1737462-A1 | PYRIMIDINES WITH TIE2 (TEK) ACTIVITY | AstraZeneca AB (SE) | 2007-01-03 | — | — | EP | disclosed |
| WO-2005060969-A1 | PYRIMIDINES WITH TIE2 (TEK) ACTIVITY | ASTRAZENECA AB (SE) | 2005-07-07 | — | — | WO | disclosed |