Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 5/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.32 |
| ▸ | SOS1 | Q07889 | 2/20 | 0.32 |
| ▸ | MYC | P01106 | 2/20 | 0.32 |
| ▸ | WDR5 | P61964 | 2/20 | 0.32 |
| ▸ | PHGDH | O43175 | 1/20 | 0.32 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | F10 | P00742 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4722245 | 1.00 | P2RX7 (0.38) | P2RX7PDE3BPDE3ANOTUMRORC | |
| SCHEMBL4724414 | 0.90 | P2RX7 (0.35) | P2RX7PDE3BPDE3ANOTUMRORC | |
| SCHEMBL4724420 | 0.90 | P2RX7 (0.35) | P2RX7PDE3BPDE3ANOTUMRORC | |
| SCHEMBL4720193 | 0.89 | SMPD3 (0.38) | — | |
| SCHEMBL4720195 | 0.89 | SMPD3 (0.38) | — | |
| SCHEMBL4724669 | 0.89 | MAPT (0.35) | P2RX7NOTUMWDR5F10 | |
| SCHEMBL4720477 | 0.89 | P2RX7 (0.37) | P2RX7PDE3BPDE3ANOTUMRORC | |
| SCHEMBL4720480 | 0.89 | P2RX7 (0.37) | P2RX7PDE3BPDE3ANOTUMRORC | |
| SCHEMBL4720304 | 0.88 | SMPD3 (0.35) | P2RX7NOTUMRORCMYCWDR5 | |
| SCHEMBL4720300 | 0.88 | SMPD3 (0.35) | P2RX7NOTUMRORCMYCWDR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1953147-A1 | HETEROCYCLIC COMPOUND AND MEDICINAL APPLICATION THEREOF | Japan Tobacco, Inc. (JP) | 2008-08-06 | — | — | EP | disclosed |