SCHEMBL4722326

SCHEMBL4722326

[c]1c(-c2cccc3cc4ccccc4cc23)ccc2ccccc12

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.36
HSD17B10 Q99714 5/20 0.36
HIF1A Q16665 4/20 0.36
CYP1B1 Q16678 1/20 0.36
KDM4E B2RXH2 2/20 0.35
GAA P10253 2/20 0.35
HPGD P15428 3/20 0.34
CASP1 P29466 3/20 0.34
TSHR P16473 2/20 0.34
MAPK1 P28482 2/20 0.34
CASP7 P55210 2/20 0.34
TP53 P04637 1/20 0.34
CYP1A2 P05177 2/20 0.34
ERBB2 P04626 1/20 0.34
FYN P06241 1/20 0.34
MAOA P21397 1/20 0.34
ACHE P22303 1/20 0.34
AHR P35869 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
CES1 P23141 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4110292 0.90 ALDH1A1 (0.36) ALDH1A1HSD17B10HIF1ACYP1B1KDM4E
SCHEMBL8733681 0.88 ALDH1A1 (0.35) ALDH1A1HSD17B10HIF1ACYP1B1KDM4E
SCHEMBL79362 0.84 ALDH1A1 (0.44) ALDH1A1HSD17B10HIF1ACYP1B1KDM4E
SCHEMBL668159 0.84 ALDH1A1 (0.41) ALDH1A1HSD17B10HIF1ACYP1B1KDM4E
SCHEMBL1186942 0.81 KDM4E (0.46) ALDH1A1HSD17B10KDM4EGAAHPGD
SCHEMBL20774242 0.81 HPRT1 (0.50) ALDH1A1HSD17B10HIF1ACYP1B1HPGD
SCHEMBL291172 0.79 ALDH1A1 (0.37) ALDH1A1HSD17B10HIF1ACYP1B1KDM4E
SCHEMBL20774036 0.79 ALDH1A1 (0.43) ALDH1A1HSD17B10HIF1ACYP1B1KDM4E
SCHEMBL9375653 0.78 ALDH1A1 (0.37) ALDH1A1HSD17B10HIF1ACYP1B1KDM4E
SCHEMBL668632 0.77 ALDH1A1 (0.38) ALDH1A1HSD17B10HIF1ACYP1B1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117279469-A Organic electroluminescent device 长春海谱润斯科技股份有限公司 2023-12-22 CN claimed
EP-3915996-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES Universal Display Corporation (US) 2021-12-01 EP disclosed
EP-3492480-B1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORP (US) 2021-10-20 EP disclosed
EP-3741768-A1 STABILIZED IMIDAZOPHENANTHRIDINE MATERIALS Universal Display Corporation (US) 2020-11-25 EP disclosed
US-10636983-B2 Organic electroluminescent materials and devices UNIVERSAL DISPLAY CORPORATION (US) 2020-04-28 US disclosed
US-20190207128-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2019-07-04 US disclosed
EP-3505524-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES Universal Display Corporation (US) 2019-07-03 EP disclosed
EP-3473635-A1 STABILIZED IMIDAZOPHENANTHRIDINE MATERIALS Universal Display Corporation (US) 2019-04-24 EP disclosed
US-20170162802-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2017-06-08 US disclosed
EP-3140871-A1 STABILIZED IMIDAZOPHENANTHRIDINE MATERIALS Universal Display Corporation (US) 2017-03-15 EP disclosed
US-6737416-B2 THROMBOLYTIC AGENT HAVING HIGHER SAFETY MEIJI SEIKA KAISHA LTD. (JP) 2004-05-18 US disclosed
US-6660718-B1 Grampositive bacteria MEIJI SEIKA KAISHA, LTD. (JP) 2003-12-09 US disclosed
US-20030119787-A1 Phosphonic acid derivative having inhibitory activity against carboxypeptidase B MEIJI SEIKA KAISHA LTD. (JP) 2003-06-26 US disclosed
US-6576627-B1 Such as 7-amino-2-((2-methyl-1-(3-phenylpropanoylamino)-propyl)hydroxyphosphinoyl) -methylheptanoic acid; thrombotic disease MEIJI SEIKA KAISHA LTD. (JP) 2003-06-10 US disclosed
EP-1152004-B1 Phosphonic acid derivatives having carboxypeptidase B inhibitory action MEIJI SEIKA KAISHA (JP) 2003-05-07 EP disclosed
EP-1191031-A1 3-MODIFIED LEUCOMYCIN DERIVATIVES MEIJI SEIKA KAISHA LTD. (JP) 2002-03-27 EP disclosed
EP-1180514-A1 NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS AND BENAMIDE COMPOUNDS AND DRUGS CONTAINING THE SAME MEIJI SEIKA KAISHA LTD. (JP) 2002-02-20 EP disclosed
EP-1174434-A1 Phosphonic acid derivative having inhibitory activity against carboxypeptidase B MEIJI SEIKA KAISHA LTD. (JP) 2002-01-23 EP disclosed
EP-1152004-A1 PHOSPHONIC ACID DERIVATIVES HAVING CARBOXYPEPTIDASE B INHIBITORY ACTIVITY MEIJI SEIKA KAISHA LTD. (JP) 2001-11-07 EP disclosed
EP-1142881-A1 POLY(ADP-RIBOSE) POLYMERASE INHIBITORS CONSISTING OF PYRIMIDINE DERIVATIVES MEIJI SEIKA KAISHA LTD. (JP) 2001-10-10 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030119787-A1 Phosphonic acid derivative having inhibitory activity against carboxypeptidase B CPB1, RNPEP, CPN1 ALDH1A1 1869/4885HSD17B10 859/4885HIF1A 1758/4885
US-20170162802-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES OCIAD2, OCIAD1, KCNQ2 ALDH1A1 954/4885HSD17B10 4013/4885HIF1A 4752/4885
US-20190207128-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES EML4, TYR, CPNE4 ALDH1A1 2007/4885HSD17B10 4713/4885HIF1A 4787/4885
US-10636983-B2 Organic electroluminescent materials and devices EML4, TYR, CPNE4 ALDH1A1 2007/4885HSD17B10 4713/4885HIF1A 4787/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.