Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 1/20 | 0.39 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.37 |
| ▸ | BRAF | P15056 | 1/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.35 |
| ▸ | TTK | P33981 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4719229 | 0.88 | IMPDH2 (0.40) | IMPDH2BRAFMCHR1PTK2P2RY1 | |
| SCHEMBL4722711 | 0.86 | MAPT (0.37) | IMPDH2AAK1LRRK2ROCK1L3MBTL1 | |
| SCHEMBL4720042 | 0.86 | IMPDH2 (0.39) | IMPDH2BRAFMCHR1PTK2P2RY1 | |
| SCHEMBL4719884 | 0.85 | L3MBTL1 (0.36) | AAK1L3MBTL1KDM4ENPC1ALDH1A1 | |
| SCHEMBL4720828 | 0.85 | IMPDH2 (0.38) | IMPDH2BRAFMCHR1PTK2P2RY1 | |
| SCHEMBL4722289 | 0.78 | IMPDH2 (0.36) | IMPDH2LRRK2BRAFPTK2P2RY1 | |
| SCHEMBL4719136 | 0.76 | MAPT (0.37) | IMPDH2PTK2L3MBTL1ALDH1A1LMNA | |
| SCHEMBL4722028 | 0.76 | MAPT (0.39) | IMPDH2PTK2P2RY1ALDH1A1LMNA | |
| SCHEMBL4723560 | 0.75 | MAPT (0.39) | IMPDH2PTK2P2RY1ALDH1A1LMNA | |
| SCHEMBL4723319 | 0.75 | MAPT (0.39) | IMPDH2PTK2P2RY1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1953147-A1 | HETEROCYCLIC COMPOUND AND MEDICINAL APPLICATION THEREOF | Japan Tobacco, Inc. (JP) | 2008-08-06 | — | — | EP | disclosed |