Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 5/20 | 0.48 |
| ▸ | DDX3X | O00571 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 4/20 | 0.43 |
| ▸ | HTR1A | P08908 | 4/20 | 0.43 |
| ▸ | HTR1D | P28221 | 3/20 | 0.43 |
| ▸ | HTR1B | P28222 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5653128 | 0.92 | CCR3 (0.46) | CCR3DDX3XNPSR1MAPK8MAPK10 | |
| SCHEMBL3198122 | 0.91 | NPC1 (0.49) | CCR3DDX3XNPSR1MAPK8MAPK10 | |
| SCHEMBL5330443 | 0.90 | CCR3 (0.44) | CCR3DDX3XNPSR1MAPK8MAPK10 | |
| SCHEMBL3211025 | 0.87 | RORC (0.46) | CCR3DDX3XNPSR1MAPK8MAPK10 | |
| SCHEMBL460041 | 0.87 | DDX3X (0.43) | CCR3DDX3XNPSR1MAPK8MAPK10 | |
| SCHEMBL3196716 | 0.87 | NPC1 (0.53) | CCR3NPSR1MAPK8MAPK10HTR1A | |
| SCHEMBL10315559 | 0.87 | HRH3 (0.46) | CCR3DDX3XNPSR1MAPK8MAPK10 | |
| SCHEMBL3199702 | 0.86 | DDX3X (0.43) | CCR3DDX3XNPSR1MAPK8MAPK10 | |
| SCHEMBL401118 | 0.85 | DDX3X (0.42) | CCR3DDX3XNPSR1MAPK8MAPK10 | |
| SCHEMBL401388 | 0.85 | MAPK10 (0.43) | CCR3DDX3XNPSR1MAPK8MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1959947-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS | Cytokinetics, Inc. (US) | 2008-08-27 | — | — | EP | disclosed |
| WO-2007075377-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS | CYTOKINETICS, INC. (US) | 2007-07-05 | — | — | WO | disclosed |