Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 11/20 | 0.54 |
| ▸ | RAB9A | P51151 | 11/20 | 0.54 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.54 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.49 |
| ▸ | PKM | P14618 | 6/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | TNF | P01375 | 1/20 | 0.49 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.49 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.47 |
| ▸ | RELA | Q04206 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4722868 | 1.00 | NPC1 (0.54) | NPC1RAB9ACDK5CDK5R1KMT2A | |
| SCHEMBL8974042 | 0.82 | NPC1 (0.42) | NPC1RAB9ACDK5CDK5R1KMT2A | |
| SCHEMBL14902858 | 0.80 | SMN1; SMN2 (0.54) | NPC1RAB9AKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL13882951 | 0.80 | SMN1; SMN2 (0.54) | NPC1RAB9AKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL6650000 | 0.80 | MASP2 (0.43) | NPC1RAB9ACDK5CDK5R1KMT2A | |
| SCHEMBL5182946 | 0.78 | NPC1 (0.37) | NPC1RAB9ACDK5CDK5R1KMT2A | |
| SCHEMBL5182951 | 0.78 | NPC1 (0.37) | NPC1RAB9ACDK5CDK5R1KMT2A | |
| SCHEMBL6007355 | 0.78 | NPC1 (0.58) | NPC1RAB9AKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL18315099 | 0.78 | RAB9A (0.60) | NPC1RAB9AKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL23901725 | 0.77 | L3MBTL1 (0.49) | NPC1RAB9ACDK5CDK5R1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080319206-A1 | Process for Preparing Protected Amidines | ASTRAZENECA AB (SE) | 2008-12-25 | — | — | US | disclosed |
| EP-1856035-B1 | PROCESS FOR PREPARAING PROTECTED AMIIDINES | ASTRAZENECA AB (SE) | 2008-12-10 | — | — | EP | disclosed |
| EP-1856035-A1 | PROCESS FOR PREPARAING PROTECTED AMIIDINES | AstraZeneca AB (SE) | 2007-11-21 | — | — | EP | disclosed |
| WO-2006090153-A1 | PROCESS FOR PREPARING PROTECTED AMIIDINES | ASTRAZENECA AB (SE) | 2006-08-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080319206-A1 | Process for Preparing Protected Amidines | HK1, HRH4, PYM1 | NPC1 1528/4885RAB9A 1272/4885CDK5 1945/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.