Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.57 |
| ▸ | USP2 | O75604 | 2/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | LMNA | P02545 | 5/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | DRD4 | P21917 | 1/20 | 0.53 |
| ▸ | DRD3 | P35462 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4718989 | 0.90 | ALDH1A1 (0.53) | SMN1; SMN2USP2MAPK1ALDH1A1LMNA | |
| SCHEMBL8247070 | 0.90 | SMN1; SMN2 (0.72) | SMN1; SMN2USP2MAPK1HSP90AA1ALDH1A1 | |
| SCHEMBL4766135 | 0.87 | USP2 (0.57) | SMN1; SMN2USP2MAPK1ALDH1A1LMNA | |
| SCHEMBL4719103 | 0.86 | ABL1 (0.55) | SMN1; SMN2USP2MAPK1ALDH1A1LMNA | |
| SCHEMBL4722493 | 0.85 | SMN1; SMN2 (0.54) | AKR1C3SMN1; SMN2USP2MAPK1ALDH1A1 | |
| SCHEMBL8247829 | 0.84 | USP2 (0.53) | SMN1; SMN2USP2MAPK1ALDH1A1LMNA | |
| SCHEMBL4722909 | 0.84 | GAA (0.60) | SMN1; SMN2USP2MAPK1ALDH1A1LMNA | |
| SCHEMBL8240451 | 0.82 | ALDH1A1 (0.60) | SMN1; SMN2USP2MAPK1ALDH1A1LMNA | |
| SCHEMBL8250360 | 0.82 | MAPK1 (0.47) | SMN1; SMN2USP2MAPK1ALDH1A1LMNA | |
| SCHEMBL4721446 | 0.79 | GAA (0.59) | SMN1; SMN2USP2ALDH1A1LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1907363-A1 | PHENYL SUBSTITUTED PIPERAZINE-DERIVATIVES AS INHIBITORS OF PLAMINOGENIC ACTIVATOR INHIBITORS-I (PAI-I) | Bayer HealthCare AG (DE) | 2008-04-09 | — | — | EP | disclosed |
| WO-2007009635-A1 | PHENYL SUBSTITUTED PIPERAZINE-DERIVATIVES AS INHIBITORS OF PLAMINOGENIC ACTIVATOR INHIBITORS-I (PAI-I) | BAYER HEALTHCARE AG (DE) | 2007-01-25 | — | — | WO | disclosed |
| WO-2007009635-A1 | PHENYL SUBSTITUTED PIPERAZINE-DERIVATIVES AS INHIBITORS OF PLAMINOGENIC ACTIVATOR INHIBITORS-I (PAI-I) | BAYER HEALTHCARE AG (DE) | 2007-01-25 | — | — | WO | disclosed |