Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.50 |
| ▸ | CCR5 | P51681 | 2/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.49 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.49 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.49 |
| ▸ | CCR3 | P51677 | 1/20 | 0.49 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25758219 | 0.80 | SLC18A3 (0.55) | HRH3CYP2D6SLC18A3CCR5CARM1 | |
| SCHEMBL7449796 | 0.79 | SIGMAR1 (0.74) | HRH3CYP2D6SIGMAR1CARM1PRMT6 | |
| SCHEMBL83059 | 0.79 | SIGMAR1 (0.69) | HRH3CYP2D6SIGMAR1CARM1PRMT6 | |
| SCHEMBL17262668 | 0.79 | DRD2 (0.68) | SIGMAR1CCR3DRD2HTR2AHTR2C | |
| SCHEMBL7444256 | 0.78 | SIGMAR1 (0.72) | HRH3CYP2D6SIGMAR1CCR3 | |
| Hydrochloric Acid SCHEMBL7451916 | 0.78 | SIGMAR1 (0.72) | HRH3CYP2D6SIGMAR1CCR3 | |
| SCHEMBL7446629 | 0.78 | SIGMAR1 (0.72) | HRH3CYP2D6SIGMAR1CCR3 | |
| SCHEMBL7444410 | 0.78 | SIGMAR1 (0.72) | HRH3CYP2D6SIGMAR1CCR3 | |
| SCHEMBL7449513 | 0.78 | SIGMAR1 (0.72) | HRH3CYP2D6SIGMAR1CCR3 | |
| SCHEMBL7437079 | 0.78 | SIGMAR1 (0.72) | HRH3CYP2D6SIGMAR1CCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2004613-A2 | BICYCLIC BENZIMIDAZOLE COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR POTENTIATORS | AstraZeneca AB (SE) | 2008-12-24 | — | — | EP | disclosed |
| WO-2007115077-A2 | BICYCLIC BENZIMIDAZOLE COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR POTENTIATORS | ASTRAZENECA AB (SE) | 2007-10-11 | — | — | WO | disclosed |