Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 8/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 8/20 | 0.39 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL472473 | 1.00 | MTNR1A (0.39) | MTNR1AMTNR1BSLC18A3EPHX2CYP1A2 | |
| SCHEMBL472495 | 0.76 | CA1 (0.48) | — | |
| SCHEMBL2062827 | 0.72 | KEAP1 (0.57) | CYP1A2CHRM2CHRM1CHRM3KEAP1 | |
| SCHEMBL3913639 | 0.72 | KEAP1 (0.57) | CYP1A2CHRM2CHRM1CHRM3KEAP1 | |
| SCHEMBL2763726 | 0.70 | KEAP1 (0.56) | CHRM2CHRM1CHRM3KEAP1NFE2L2 | |
| SCHEMBL7262280 | 0.68 | SLC18A3 (0.39) | MTNR1AMTNR1BSLC18A3EPHX2CHRM2 | |
| SCHEMBL14433304 | 0.68 | CHRM2 (0.44) | MTNR1AMTNR1BCYP1A2CYP2C9CHRM2 | |
| SCHEMBL23059594 | 0.67 | CHRM2 (0.39) | MTNR1AMTNR1BCYP1A2CYP2C9CHRM2 | |
| SCHEMBL24191927 | 0.67 | CHRM2 (0.39) | MTNR1AMTNR1BCYP1A2CYP2C9CHRM2 | |
| SCHEMBL1965788 | 0.66 | MTNR1A (0.52) | MTNR1AMTNR1BEPHX2CYP1A2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2412372-A1 | 2-Aminooxazole derivatives for use as TRPV1 antagonists for treating i.a. pain, inflammation, neurodegenerative diseases or gastrointestinal diseases | Abbott Laboratories (US) | 2012-02-01 | — | — | EP | disclosed |
| US-7998993-B2 | TRPV1 antagonists | ABBOTT LABORATORIES (US) | 2011-08-16 | — | — | US | disclosed |