Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB2 | P05107 | 2/20 | 0.40 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.40 |
| ▸ | ITGAL | P20701 | 2/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.39 |
| ▸ | UGCG | Q16739 | 1/20 | 0.37 |
| ▸ | NTSR1 | P30989 | 5/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.36 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.36 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | F10 | P00742 | 2/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4723510 | 1.00 | ITGB2 (0.40) | ITGB2ICAM1ITGALPDE4APDE4B | |
| SCHEMBL4720711 | 0.90 | P2RX7 (0.42) | P2RX7PDE7AHSD11B1 | |
| SCHEMBL4720706 | 0.90 | P2RX7 (0.42) | P2RX7PDE7AHSD11B1 | |
| SCHEMBL4722448 | 0.89 | RORC (0.41) | P2RX7HSD11B1 | |
| SCHEMBL4721711 | 0.89 | P2RX7 (0.39) | P2RX7HSD11B1F10 | |
| SCHEMBL4721709 | 0.89 | P2RX7 (0.39) | P2RX7HSD11B1F10 | |
| SCHEMBL4722454 | 0.89 | RORC (0.41) | P2RX7HSD11B1 | |
| SCHEMBL4723309 | 0.88 | P2RX7 (0.42) | P2RX7SLC6A9 | |
| SCHEMBL4724116 | 0.88 | P2RX7 (0.39) | P2RX7HSD11B1F10 | |
| SCHEMBL4723314 | 0.88 | P2RX7 (0.42) | P2RX7SLC6A9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1953147-A1 | HETEROCYCLIC COMPOUND AND MEDICINAL APPLICATION THEREOF | Japan Tobacco, Inc. (JP) | 2008-08-06 | — | — | EP | disclosed |