Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.52 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4766661 | 1.00 | SMN1; SMN2 (0.61) | SMN1; SMN2ALDH1A1KDM4ETDP1LMNA | |
| SCHEMBL11063217 | 0.87 | SMN1; SMN2 (0.62) | SMN1; SMN2ALDH1A1KDM4ETDP1LMNA | |
| SCHEMBL4724317 | 0.82 | NPC1 (0.48) | SMN1; SMN2ALDH1A1KDM4ETDP1LMNA | |
| SCHEMBL4722633 | 0.82 | AKT1 (0.47) | SMN1; SMN2ALDH1A1KDM4ETDP1LMNA | |
| SCHEMBL11070668 | 0.81 | SMN1; SMN2 (0.57) | SMN1; SMN2ALDH1A1KDM4ETDP1LMNA | |
| SCHEMBL11062633 | 0.81 | ALDH1A1 (0.64) | SMN1; SMN2ALDH1A1KDM4ETDP1LMNA | |
| SCHEMBL2556236 | 0.81 | ALDH1A1 (0.52) | SMN1; SMN2ALDH1A1KDM4ELMNAADRB2 | |
| SCHEMBL15951817 | 0.80 | SMN1; SMN2 (0.54) | SMN1; SMN2ALDH1A1KDM4ETDP1LMNA | |
| SCHEMBL31697363 | 0.80 | KDM4E (0.54) | SMN1; SMN2ALDH1A1KDM4ETDP1HRH3 | |
| SCHEMBL11004804 | 0.80 | ALDH1A1 (0.63) | SMN1; SMN2ALDH1A1KDM4ETDP1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1917262-A1 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS P2X3 ANTAGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-05-07 | — | — | EP | disclosed |
| WO-2007020194-A1 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS P2X3 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-02-22 | — | — | WO | disclosed |