Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 1/20 | 0.47 |
| ▸ | SORD | Q00796 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 2/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.41 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4723632 | 0.82 | SMN1; SMN2 (0.61) | SMN1; SMN2KDM4EALDH1A1TDP1LMNA | |
| SCHEMBL4766661 | 0.82 | SMN1; SMN2 (0.61) | SMN1; SMN2KDM4EALDH1A1TDP1LMNA | |
| SCHEMBL23759638 | 0.81 | SORD (0.51) | AKT1SORDPARP1GPR119GRM1 | |
| SCHEMBL4723624 | 0.79 | KDM4E (0.49) | SORDGPR119SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL9767811 | 0.76 | — | — | |
| SCHEMBL25168553 | 0.76 | OGA (0.58) | AKT1SORDPARP1GPR119 | |
| SCHEMBL25168554 | 0.76 | OGA (0.58) | AKT1SORDPARP1GPR119 | |
| SCHEMBL9371315 | 0.75 | AKT1 (0.55) | AKT1SORDPARP1GPR119GRM1 | |
| SCHEMBL4724317 | 0.75 | NPC1 (0.48) | SMN1; SMN2KDM4EALDH1A1TDP1LMNA | |
| SCHEMBL5758520 | 0.73 | SORD (0.54) | AKT1SORDPARP1GPR119GRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1917262-A1 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS P2X3 ANTAGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-05-07 | — | — | EP | disclosed |
| WO-2007020194-A1 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS P2X3 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-02-22 | — | — | WO | disclosed |