Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 12/20 | 0.51 |
| ▸ | FLT3 | P36888 | 3/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.35 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | PRKDC | P78527 | 1/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4719883 | 0.90 | GPR119 (0.51) | GPR119FLT3CDK2CDK6CYP2C9 | |
| SCHEMBL4719420 | 0.88 | GPR119 (0.61) | GPR119FLT3CDK2CDK6CYP2C9 | |
| SCHEMBL390253 | 0.88 | GPR119 (0.60) | GPR119CYP2C9KCNH2IKBKETBK1 | |
| SCHEMBL4719405 | 0.86 | GPR119 (0.48) | GPR119FLT3CDK2CDK6 | |
| SCHEMBL4719749 | 0.85 | GPR119 (0.45) | GPR119FLT3CDK2CDK6IKBKE | |
| SCHEMBL4720714 | 0.84 | GPR119 (0.40) | GPR119FLT3CDK2CDK6 | |
| SCHEMBL4722024 | 0.83 | GPR119 (0.40) | GPR119IKBKETBK1 | |
| SCHEMBL4720455 | 0.82 | GPR119 (0.42) | GPR119FLT3CDK2CDK6PIK3CA | |
| SCHEMBL4719081 | 0.81 | GPR119 (0.48) | GPR119FLT3CDK2CDK6 | |
| SCHEMBL4721934 | 0.81 | GPR119 (0.51) | GPR119FLT3CDK2CDK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756084-B1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARM INC (US) | 2008-11-26 | — | — | EP | claimed |