Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.51 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 2/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | FLT1 | P17948 | 1/20 | 0.42 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 4/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.36 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.36 |
| ▸ | TRPC6 | Q9Y210 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4719081 | 0.89 | GPR119 (0.48) | GPR119KDRBRAFCDK2FLT3 | |
| SCHEMBL4718549 | 0.88 | GPR119 (0.46) | GPR119MKNK1KDREGFRSCN9A | |
| SCHEMBL390190 | 0.88 | GPR119 (0.60) | GPR119MKNK1USP30 | |
| SCHEMBL4719030 | 0.88 | GPR119 (0.67) | GPR119 | |
| SCHEMBL4721156 | 0.86 | GPR119 (0.46) | GPR119KDRSCN9ABRAFCDK2 | |
| SCHEMBL4719883 | 0.85 | GPR119 (0.51) | GPR119EGFRCDK2FLT3CDK6 | |
| SCHEMBL4719749 | 0.85 | GPR119 (0.45) | GPR119EGFRCDK2FLT3CDK6 | |
| SCHEMBL4723743 | 0.84 | GPR119 (0.52) | GPR119 | |
| SCHEMBL4718480 | 0.84 | GPR119 (0.44) | GPR119SCN9ACDK2FLT3CDK6 | |
| SCHEMBL4723151 | 0.83 | GPR119 (0.44) | GPR119CDK2CDK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756084-B1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARM INC (US) | 2008-11-26 | — | — | EP | claimed |