Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.33 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.33 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.32 |
| ▸ | EGFR | P00533 | 2/20 | 0.32 |
| ▸ | FLT1 | P17948 | 2/20 | 0.32 |
| ▸ | FLT4 | P35916 | 2/20 | 0.32 |
| ▸ | KDR | P35968 | 2/20 | 0.32 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | PRKDC | P78527 | 1/20 | 0.31 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4720553 | 0.93 | S1PR1 (0.37) | S1PR1GPR119KDRTBK1 | |
| SCHEMBL4719712 | 0.91 | S1PR1 (0.36) | S1PR1GPR119EGFRKDRTBK1 | |
| SCHEMBL389745 | 0.89 | SCN9A (0.43) | CYP3A4CYP2C9GPR119SCN9ATBK1 | |
| SCHEMBL4723222 | 0.89 | GPR119 (0.38) | S1PR1CYP3A4CYP2C9GPR119 | |
| SCHEMBL27755095 | 0.85 | GPR119 (0.37) | S1PR1FGFR1FGFR4FGFR3CYP3A4 | |
| SCHEMBL4723218 | 0.84 | GPR119 (0.46) | CYP3A4CYP2C9GPR119 | |
| SCHEMBL4720580 | 0.82 | TBK1 (0.37) | S1PR1ABL1PTK6GPR119EGFR | |
| SCHEMBL388861 | 0.81 | GPR119 (0.45) | CYP3A4CYP2C9GPR119SCN9ATBK1 | |
| SCHEMBL386351 | 0.80 | GPR119 (0.43) | CYP3A4CYP2C9GPR119SCN9ATBK1 | |
| SCHEMBL4723661 | 0.80 | GPR119 (0.38) | CYP3A4CYP2C9GPR119TBK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756084-B1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARM INC (US) | 2008-11-26 | — | — | EP | claimed |