Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 4/20 | 0.37 |
| ▸ | ACACB | O00763 | 2/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.33 |
| ▸ | KDR | P35968 | 2/20 | 0.32 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.32 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.32 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.32 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.32 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.30 |
| ▸ | IDO1 | P14902 | 1/20 | 0.30 |
| ▸ | ABL1 | P00519 | 1/20 | 0.30 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4719712 | 0.91 | S1PR1 (0.36) | TBK1GPR119KDRERBB2EPHA2 | |
| SCHEMBL4724030 | 0.91 | KDR (0.39) | TBK1KDRERBB2EPHA2EPHB4 | |
| SCHEMBL4723661 | 0.90 | GPR119 (0.38) | TBK1ACACBGPR119 | |
| SCHEMBL4719875 | 0.89 | MKNK1 (0.39) | TBK1ACACBGPR119KDR | |
| SCHEMBL389718 | 0.89 | TBK1 (0.44) | TBK1GPR119IDO1 | |
| SCHEMBL4724482 | 0.89 | GPR119 (0.38) | TBK1ACACBGPR119AAK1 | |
| SCHEMBL4763290 | 0.89 | TBK1 (0.40) | TBK1ACACBGPR119CACNA1HAAK1 | |
| SCHEMBL4723185 | 0.88 | TBK1 (0.38) | TBK1ACACBGPR119KDREGFR | |
| SCHEMBL4722370 | 0.88 | TBK1 (0.39) | TBK1ACACBGPR119CACNA1H | |
| SCHEMBL4718652 | 0.88 | TBK1 (0.39) | TBK1ACACBGPR119CACNA1HABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756084-B1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARM INC (US) | 2008-11-26 | — | — | EP | claimed |