Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | PTGDR2 | Q9Y5Y4 | 13/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.41 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4765488 | 1.00 | KMT2A (0.52) | KMT2AMAPTMEN1SMN1; SMN2PTGDR2 | |
| SCHEMBL4721901 | 0.95 | KMT2A (0.49) | KMT2AMAPTMEN1SMN1; SMN2PTGDR2 | |
| SCHEMBL9998826 | 0.84 | MEN1 (0.52) | KMT2AMAPTMEN1SMN1; SMN2PTGDR2 | |
| SCHEMBL4498016 | 0.84 | MEN1 (0.52) | KMT2AMAPTMEN1SMN1; SMN2PTGDR2 | |
| SCHEMBL9998261 | 0.78 | MAPT (0.49) | KMT2AMAPTNPSR1 | |
| SCHEMBL4766610 | 0.73 | NR4A2 (0.54) | KMT2AMEN1KDM4EHPGDCYP2C19 | |
| SCHEMBL12608913 | 0.72 | KMT2A (0.65) | KMT2AMAPTMEN1SMN1; SMN2PTGDR2 | |
| SCHEMBL12608906 | 0.71 | PTGDR2 (0.81) | KMT2AMAPTMEN1SMN1; SMN2PTGDR2 | |
| Fentiazac SCHEMBL16196751 | 0.70 | PTGDR2 (1.00) | KMT2AMAPTMEN1SMN1; SMN2PTGDR2 | |
| Fentiazac SCHEMBL24355 | 0.70 | PTGDR2 (1.00) | KMT2AMAPTMEN1SMN1; SMN2PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1917262-A1 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS P2X3 ANTAGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-05-07 | — | — | EP | disclosed |
| WO-2007020194-A1 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS P2X3 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-02-22 | — | — | WO | disclosed |