Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 6/20 | 0.47 |
| ▸ | METAP1 | P53582 | 2/20 | 0.47 |
| ▸ | METAP2 | P50579 | 1/20 | 0.47 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.45 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 4/20 | 0.43 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.41 |
| ▸ | FBP1 | P09467 | 2/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6829765 | 0.80 | MMP2 (0.56) | HPSEFBP1 | |
| SCHEMBL4725284 | 0.79 | FBP1 (0.41) | FBP1 | |
| SCHEMBL4726376 | 0.73 | FBP1 (0.50) | FBP1 | |
| SCHEMBL6830045 | 0.73 | CBFB (0.44) | FBP1 | |
| SCHEMBL1170747 | 0.73 | METAP1 (0.72) | PDE5AMETAP1METAP2HPSEPRMT5 | |
| SCHEMBL28522563 | 0.72 | NUDT1 (0.51) | PDE5AMETAP1METAP2HPSEPRMT5 | |
| SCHEMBL4796357 | 0.72 | FBP1 (0.53) | FBP1 | |
| SCHEMBL6829687 | 0.71 | GUSB (0.49) | METAP1METAP2HPSEFBP1 | |
| SCHEMBL6829684 | 0.71 | RHEB (0.46) | FBP1 | |
| SCHEMBL6829661 | 0.71 | KDM4E (0.46) | FBP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008019309-A1 | NOVEL INHIBITORS OF FRUCTOSE 1,6-BISPHOSPHATASE | METABASIS THERAPEUTICS, INC. (US) | 2008-02-14 | — | — | WO | disclosed |