Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.67 |
| ▸ | NPC1 | O15118 | 9/20 | 0.65 |
| ▸ | RAB9A | P51151 | 9/20 | 0.65 |
| ▸ | TP53 | P04637 | 4/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | TSHR | P16473 | 2/20 | 0.61 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.60 |
| ▸ | GAA | P10253 | 3/20 | 0.60 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.60 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.60 |
| ▸ | RELA | Q04206 | 2/20 | 0.60 |
| ▸ | HPGD | P15428 | 4/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1494896 | 0.86 | ALDH1A1 (0.71) | ALDH1A1KDM4EKMT2AMEN1NPC1 | |
| SCHEMBL1494792 | 0.83 | ALDH1A1 (0.67) | ALDH1A1KDM4EKMT2AMEN1NPC1 | |
| SCHEMBL1494793 | 0.83 | TP53 (0.78) | ALDH1A1KDM4EKMT2AMEN1NPC1 | |
| SCHEMBL1494878 | 0.83 | KDM4E (0.78) | ALDH1A1KDM4EKMT2AMEN1NPC1 | |
| SCHEMBL12726227 | 0.83 | ALDH1A1 (0.61) | ALDH1A1KDM4EKMT2AMEN1NPC1 | |
| SCHEMBL1495011 | 0.82 | KDM4E (0.69) | ALDH1A1KDM4EKMT2AMEN1NPC1 | |
| SCHEMBL24733341 | 0.81 | KDM4E (0.74) | ALDH1A1KDM4EKMT2AMEN1NPC1 | |
| SCHEMBL12726066 | 0.81 | ALDH1A1 (0.68) | ALDH1A1KDM4EKMT2AMEN1NPC1 | |
| SCHEMBL4728069 | 0.81 | NPC1 (0.67) | ALDH1A1KDM4EKMT2AMEN1NPC1 | |
| SCHEMBL1494779 | 0.81 | KDM4E (1.00) | ALDH1A1KDM4EKMT2AMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008029152-A2 | TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | SUMMIT CORPORATION PLC (GB) | 2008-03-13 | — | — | WO | disclosed |