Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.74 |
| ▸ | MEN1 | O00255 | 1/20 | 0.74 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.73 |
| ▸ | RAB9A | P51151 | 8/20 | 0.66 |
| ▸ | NPC1 | O15118 | 5/20 | 0.65 |
| ▸ | HPGD | P15428 | 2/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | GAA | P10253 | 3/20 | 0.58 |
| ▸ | GLA | P06280 | 2/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.57 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.57 |
| ▸ | RELA | Q04206 | 2/20 | 0.57 |
| ▸ | TP53 | P04637 | 6/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1494878 | 0.91 | KDM4E (0.78) | KDM4EALDH1A1KMT2AMEN1HRH3 | |
| SCHEMBL1514674 | 0.90 | KDM4E (0.77) | KDM4EALDH1A1KMT2AMEN1HRH3 | |
| SCHEMBL5406505 | 0.88 | KDM4E (0.68) | KDM4EALDH1A1KMT2AMEN1HRH3 | |
| SCHEMBL1494779 | 0.85 | KDM4E (1.00) | KDM4EALDH1A1KMT2AMEN1HRH3 | |
| SCHEMBL1494896 | 0.84 | ALDH1A1 (0.71) | KDM4EALDH1A1KMT2AMEN1HRH3 | |
| SCHEMBL5413898 | 0.84 | HRH3 (1.00) | KDM4EALDH1A1KMT2AMEN1HRH3 | |
| SCHEMBL5419331 | 0.83 | HRH3 (0.80) | KDM4EALDH1A1KMT2AMEN1HRH3 | |
| SCHEMBL4725484 | 0.81 | ALDH1A1 (0.67) | KDM4EALDH1A1KMT2AMEN1HRH3 | |
| SCHEMBL1494792 | 0.81 | ALDH1A1 (0.67) | KDM4EALDH1A1KMT2AMEN1HRH3 | |
| SCHEMBL1494793 | 0.81 | TP53 (0.78) | KDM4EALDH1A1KMT2AMEN1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11413278-B2 | Compounds and methods for promoting stress resistance | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2022-08-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11413278-B2 | Compounds and methods for promoting stress resistance | HSPA9, ATF4, GPX4 | KDM4E 4057/4885ALDH1A1 1459/4885KMT2A 2884/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.