SCHEMBL4725531

SCHEMBL4725531

NC(CCCCN1C(=O)CSC1=O)COc1cccc2ccccc12

nearest known ligand 0.41

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 1/20 0.40
NR2E1 Q9Y466 1/20 0.39
TSHR P16473 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
HRH3 Q9Y5N1 4/20 0.38
HTR2A P28223 2/20 0.38
HTR7 P34969 2/20 0.38
HTR6 P50406 2/20 0.38
MEN1 O00255 2/20 0.38
KMT2A Q03164 2/20 0.38
KDM4E B2RXH2 1/20 0.38
CYP1A2 P05177 1/20 0.38
CYP2C19 P33261 1/20 0.38
HTR1B P28222 1/20 0.37
ALDH1A1 P00352 1/20 0.37
GSK3A P49840 1/20 0.36
GSK3B P49841 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4729790 0.82 ALDH1A1 (0.46) TSHRMEN1KMT2AALDH1A1GSK3A
SCHEMBL4727354 0.82 PIM1 (0.41) TSHRL3MBTL1HTR7MEN1KMT2A
SCHEMBL5768086 0.78 HTR1A (0.58) TDP1NR2E1HRH3HTR2AHTR7
SCHEMBL4782386 0.75 HTR1A (0.66)
SCHEMBL11413078 0.66 CYP1A2 (0.69) TDP1NR2E1TSHRHTR2AHTR6
SCHEMBL7846002 0.65 ALDH1A1 (0.44) TSHRMEN1KMT2AALDH1A1GSK3A
SCHEMBL7635264 0.65 PIM1 (0.64) L3MBTL1ALDH1A1GSK3AGSK3B
SCHEMBL11553112 0.65 TSHR (0.57) TDP1NR2E1TSHRL3MBTL1HRH3
SCHEMBL7841647 0.65 HTR1A (0.61) HTR2AHTR7HTR6CYP1A2HTR1B
SCHEMBL5679175 0.64 HTR1B (0.58) TDP1NR2E1HRH3HTR2AHTR7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008015538-A2 USE OF DIAZA- AND THIAZA-CYCLOALKANEDIONES FOR PREVENTING AND/OR TREATING PAIN AND /OR MIGRAINE SCHWARZ PHARMA S.L. (ES) 2008-02-07 WO claimed
WO-2008015538-A2 USE OF DIAZA- AND THIAZA-CYCLOALKANEDIONES FOR PREVENTING AND/OR TREATING PAIN AND /OR MIGRAINE SCHWARZ PHARMA S.L. (ES) 2008-02-07 WO disclosed