Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 8/20 | 0.62 |
| ▸ | DRD2 | P14416 | 8/20 | 0.62 |
| ▸ | HTR2A | P28223 | 8/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.62 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4728831 | 0.95 | DRD2 (0.69) | HTR1ADRD2HTR2AKCNH2MAPT | |
| SCHEMBL4728930 | 0.82 | DRD2 (0.91) | HTR1ADRD2HTR2AKCNH2SLC6A2 | |
| SCHEMBL4729828 | 0.79 | HTR1A (0.72) | HTR1ADRD2HTR2AKCNH2SLC6A4 | |
| SCHEMBL4726781 | 0.79 | HTR1A (0.62) | HTR1ADRD2HTR2AKCNH2SLC6A4 | |
| SCHEMBL4725686 | 0.77 | DRD2 (1.00) | HTR1ADRD2HTR2AKCNH2SLC6A4 | |
| SCHEMBL4725843 | 0.76 | DRD2 (1.00) | HTR1ADRD2HTR2AKCNH2SLC6A2 | |
| SCHEMBL4729824 | 0.75 | DRD2 (0.51) | HTR1ADRD2HTR2AKCNH2MAPT | |
| SCHEMBL4726778 | 0.75 | HTR2A (0.49) | HTR1ADRD2HTR2AKCNH2MAPT | |
| SCHEMBL4727401 | 0.74 | DRD2 (0.90) | HTR1ADRD2HTR2AKCNH2SLC6A4 | |
| SCHEMBL4730243 | 0.73 | DRD2 (0.66) | HTR1ADRD2HTR2AKCNH2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008020306-A2 | ISOINDOLE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 2008-02-21 | — | — | WO | claimed |