Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB2 | P30411 | 1/20 | 0.34 |
| ▸ | PPM1D | O15297 | 1/20 | 0.34 |
| ▸ | VHL | P40337 | 1/20 | 0.31 |
| ▸ | ELOC | Q15369 | 1/20 | 0.31 |
| ▸ | ELOB | Q15370 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19834205 | 0.89 | PPM1D (0.33) | PPM1D | |
| SCHEMBL4416435 | 0.88 | PPM1D (0.33) | PPM1DVHLELOCELOB | |
| SCHEMBL3433762 | 0.88 | PPM1D (0.33) | PPM1D | |
| SCHEMBL3525995 | 0.87 | PPM1D (0.34) | PPM1D | |
| SCHEMBL29245844 | 0.87 | PPM1D (0.34) | PPM1D | |
| SCHEMBL376587 | 0.87 | PPM1D (0.34) | PPM1D | |
| SCHEMBL2634064 | 0.87 | PPM1D (0.34) | PPM1D | |
| SCHEMBL5314317 | 0.87 | PPM1D (0.34) | PPM1D | |
| SCHEMBL30729563 | 0.87 | PPM1D (0.34) | PPM1D | |
| SCHEMBL3470472 | 0.87 | PPM1D (0.34) | PPM1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008028662-A1 | N-[1-(3-AMINO-4-PHENYL-BUTYRYL)-4-HYDROXY-PYRROLIDIN-2-YLMETHYL}-PROPIONAMIDE AND RELATED COMPOUNDS AS DPP-IV INHIBITORS FOR THE TREATMENT OF TYPE 2 DIABETES MELLITUS | SANTHERA PHARMACEUTICALS (SCHWEIZ) AG (CH) | 2008-03-13 | — | — | WO | disclosed |