SCHEMBL472609

SCHEMBL472609

OC[C@H]1O[C@@H](n2cnc3c(NC4CCCC4)nc(Cl)nc32)C(O)C1O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
ADORA3 P0DMS8 8/20 1.00
ADORA2A P29274 6/20 1.00
ADORA1 P30542 5/20 1.00
ADORA2B P29275 4/20 1.00
MEN1 O00255 1/20 1.00
CYP1A2 P05177 1/20 1.00
MAPK1 P28482 1/20 1.00
KMT2A Q03164 1/20 1.00
RXFP1 Q9HBX9 1/20 0.98
HTR2C P28335 1/20 0.75
PMP22 Q01453 1/20 0.73

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2492838 1.00 ADORA3 (1.00) ADORA3ADORA2AADORA1ADORA2BMEN1
SCHEMBL29354999 1.00 ADORA3 (1.00) ADORA3ADORA2AADORA1ADORA2BMEN1
SCHEMBL16081269 1.00 ADORA3 (1.00) ADORA3ADORA2AADORA1ADORA2BMEN1
SCHEMBL120439 1.00 ADORA3 (1.00) ADORA3ADORA2AADORA1ADORA2BMEN1
SCHEMBL2461163 1.00 ADORA3 (1.00) ADORA3ADORA2AADORA1ADORA2BMEN1
SCHEMBL12264514 1.00 ADORA3 (1.00) ADORA3ADORA2AADORA1ADORA2BMEN1
SCHEMBL19807522 1.00 ADORA3 (1.00) ADORA3ADORA2AADORA1ADORA2BMEN1
SCHEMBL3950346 1.00 ADORA3 (1.00) ADORA3ADORA2AADORA1ADORA2BMEN1
SCHEMBL9498481 0.99 ADORA3 (0.98) ADORA3ADORA2AADORA1ADORA2BMEN1
SCHEMBL4803030 0.99 ADORA3 (0.98) ADORA3ADORA2AADORA1ADORA2BMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 366 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118845814-A Application of N6-cyclopentyl adenosine, derivatives and salts thereof in treating liver diseases 上海中医药大学 2024-10-29 CN claimed
US-20240024243-A1 Fine Dry Particulate Adenosine Compositions and Topical Formulations Including the Same LABORATORY SKIN CARE, INC. 2024-01-25 US claimed
CN-111789950-A Method and pharmaceutical composition for regulating fear memory consolidation 浙江大学 2020-10-20 CN claimed
EP-2704793-B1 REGULATION OF AMYLOID BETA MOLECULAR COMPOSITION FOR THE TREATMENT OF ALZHEIMER'S DISEASE UNIV RAMOT (IL) 2019-07-17 EP claimed
US-20180344655-A1 FUNCTIONALIZED POLYMERIC PARTICLES FOR TREATMENT OF GLIOMAS YALE UNIVERSITY 2018-12-06 US claimed
WO-2016183217-A1 FUNCTIONALIZED POLYMERIC PARTICLES FOR TREATMENT OF GLIOMAS YALE UNIVERSITY (US) 2016-11-17 WO claimed
EP-2204154-B1 Association of monosaccharides and adenosine and its cosmetic use ORÉAL L (FR) 2016-10-12 EP claimed
US-9192670-B2 Regulation of amyloid beta molecular composition for the treatment of alzheimer's disease RAMOT AT TEL-AVIV UNIVERSITY LTD. (IL) 2015-11-24 US claimed
US-20140147516-A1 POLYMORPHISMS PREDICTIVE OF PLATINUM-COORDINATING COMPOUND-INDUCED OTOTOXICITY THE UNIVERSITY OF BRITISH COLUMBIA (CA) 2014-05-29 US claimed
EP-2704793-A1 REGULATION OF AMYLOID BETA MOLECULAR COMPOSITION FOR THE TREATMENT OF ALZHEIMER'S DISEASE Ramot at Tel Aviv University, Ltd. (IL) 2014-03-12 EP claimed
US-20100168049-A1 COMBINATION OF MONOSACCHARIDES AND ADENOSINE AND USE THEREOF L'OREAL (FR) 2010-07-01 US claimed
WO-2009124396-A1 POLYMORPHISMS PREDICTIVE OF PLATINUM-COORDINATING COMPOUND-INDUCED OTOTOXICITY THE UNIVERSITY OF BRITISH COLUMBIA (CA) 2009-10-15 WO claimed
US-20070232560-A1 Treatment of skin with adenosine or adenosine analog UNIVERSITY OF MASSACHUSETTS, A MASSACHUSETTS CORPORATION 2007-10-04 US claimed
EP-1424064-B1 Use of adenosin or an adenosin analog to smooth out fine lines OREAL (FR) 2007-06-06 EP claimed
WO-2007042679-A2 COSMETIC COMPOSITION CONTAINING A NON-PHOSPHATE COMPOUND BASED ON ADENOSINE AND A TIGHTENING POLYMER L'OREAL (FR) 2007-04-19 WO claimed
US-20060240056-A1 Treatment of skin with adenosine or adenosine analog UNIVERSITY OF MASSACHUSETTS, A MASSACHUSETTS CORPORATION 2006-10-26 US claimed
EP-1638579-A2 COMPOSITIONS AND METHODS FOR USE OF A PROTEASE INHIBITOR AND ADENOSINE FOR PREVENTING ORGAN ISCHEMIA AND REPERFUSION INJURY EMORY UNIVERSITY (US) 2006-03-29 EP claimed
WO-2005003150-A2 COMPOSITIONS AND METHODS FOR USE OF A PROTEASE INHIBITOR AND ADENOSINE FOR PREVENTING ORGAN ISCHEMIA AND REPERFUSION INJURY EMORY UNIVERSITY (US) 2005-01-13 WO claimed
EP-1424064-A1 Use of adenosin or an adenosin analog to smooth out fine lines L'OREAL (FR) 2004-06-02 EP claimed
US-5998423-A IN SKIN OR HAIR; ADMINISTERING ADENOSINE RECEPTOR ANTAGONIST THERASYS, INC. (US) 1999-12-07 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180344655-A1 FUNCTIONALIZED POLYMERIC PARTICLES FOR TREATMENT OF GLIOMAS PHLPP1, PHLPP2, PLAA ADORA3 32/4885ADORA2A 10/4885ADORA1 39/4885
US-20100168049-A1 COMBINATION OF MONOSACCHARIDES AND ADENOSINE AND USE THEREOF ADORA2A, ADORA1, ADORA3 ADORA3 3/4885ADORA2A 1/4885ADORA1 2/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.