Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | KDM4C | Q9H3R0 | 9/20 | 0.41 |
| ▸ | KDM5A | P29375 | 9/20 | 0.41 |
| ▸ | PHF8 | Q9UPP1 | 2/20 | 0.41 |
| ▸ | KDM4A | O75164 | 2/20 | 0.41 |
| ▸ | THRA | P10827 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | KDM5C | P41229 | 1/20 | 0.39 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3317557 | 0.91 | LTA4H (0.39) | CHRM2KDM4CKDM5APHF8KDM4A | |
| SCHEMBL3319751 | 0.85 | KMT2A (0.41) | THRATHRBMEN1KMT2ALTA4H | |
| SCHEMBL12051225 | 0.83 | GPR84 (0.54) | KDM4CKDM5APHF8KDM4AKDM5C | |
| SCHEMBL26495622 | 0.83 | GPR84 (0.54) | KDM4CKDM5APHF8KDM4AKDM5C | |
| SCHEMBL26495489 | 0.83 | GPR84 (0.54) | KDM4CKDM5APHF8KDM4AKDM5C | |
| SCHEMBL30074288 | 0.82 | LTA4H (0.47) | CHRM2KDM4CKDM5APHF8KDM4A | |
| SCHEMBL27972459 | 0.82 | LTA4H (0.42) | CHRM2KDM4CKDM5APHF8KDM4A | |
| SCHEMBL15233375 | 0.82 | CHRM2 (0.52) | CHRM2KDM4CKDM5APHF8KDM4A | |
| SCHEMBL26495422 | 0.81 | KDM4C (0.51) | KDM4CKDM5APHF8KDM4AKDM5C | |
| Octadecanoic Acid Amide SCHEMBL7165770 | 0.79 | S1PR2 (0.46) | KDM4CKDM5APHF8THRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008015437-A1 | PYRAZOLO[3,4-B]PYRIDINE COMPOUNDS, AND THEIR USE AS PDE4 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2008-02-07 | — | — | WO | claimed |
| WO-2008015437-A1 | PYRAZOLO[3,4-B]PYRIDINE COMPOUNDS, AND THEIR USE AS PDE4 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2008-02-07 | — | — | WO | disclosed |