Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | PPARD | Q03181 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4726322 | 1.00 | ALDH1A1 (0.38) | ALDH1A1LMNAHTTTAAR1KMT2A | |
| SCHEMBL8612062 | 0.87 | ALDH1A1 (0.36) | ALDH1A1LMNAHTTTAAR1KMT2A | |
| SCHEMBL8610635 | 0.79 | NPC1 (0.43) | ALDH1A1LMNAHTTTAAR1KMT2A | |
| SCHEMBL8553787 | 0.79 | NPC1 (0.47) | ALDH1A1TAAR1KMT2AMEN1NPC1 | |
| SCHEMBL8553789 | 0.79 | NPC1 (0.47) | ALDH1A1TAAR1KMT2AMEN1NPC1 | |
| SCHEMBL4728458 | 0.77 | ALOX5 (0.38) | ALDH1A1LMNAHTTTAAR1KMT2A | |
| SCHEMBL5086406 | 0.77 | ALOX5 (0.38) | ALDH1A1LMNAHTTTAAR1KMT2A | |
| SCHEMBL8612736 | 0.74 | NPC1 (0.47) | ALDH1A1TAAR1KMT2AMEN1NPC1 | |
| SCHEMBL8304852 | 0.71 | MAPT (0.48) | ALDH1A1LMNAHTTTAAR1KMT2A | |
| SCHEMBL8304850 | 0.71 | MAPT (0.48) | ALDH1A1LMNAHTTTAAR1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021210-A2 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | COMBINATORX, INCORPORATED (US) | 2008-02-21 | — | — | WO | disclosed |