Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.44 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | INPP5D | Q92835 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8304852 | 1.00 | MAPT (0.48) | MAPTALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL25746548 | 0.88 | MAPT (0.55) | MAPTALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL25746558 | 0.88 | MAPT (0.55) | MAPTALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8308681 | 0.83 | MAPT (0.48) | MAPTALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8308678 | 0.83 | MAPT (0.48) | MAPTALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL29708126 | 0.82 | MAPT (0.61) | MAPTALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7689039 | 0.82 | MAPT (0.61) | MAPTALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8611007 | 0.78 | MAPT (0.41) | MAPTALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8611012 | 0.78 | MAPT (0.41) | MAPTALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8303260 | 0.78 | ALDH1A1 (0.42) | MAPTALDH1A1NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832078-B1 | N-HYDROXYUREAS AS ANTIINFLAMMATORY AGENTS | PFIZER (US) | 1999-10-20 | — | — | EP | disclosed |
| US-5814648-A | N-hydroxyureas as antiinflammatory agents | PFIZER INC. (US) | 1998-09-29 | — | — | US | disclosed |
| EP-0832078-A1 | N-HYDROXYUREAS AS ANTIINFLAMMATORY AGENTS | PFIZER INC. (US) | 1998-04-01 | — | — | EP | disclosed |
| WO-1996040659-A1 | N-HYDROXYUREAS AS ANTIINFLAMMATORY AGENTS | PFIZER INC. (US) | 1996-12-19 | — | — | WO | disclosed |