Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 9/20 | 0.73 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.73 |
| ▸ | TLR4 | O00206 | 4/20 | 0.67 |
| ▸ | DRD2 | P14416 | 3/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.64 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.64 |
| ▸ | MAPT | P10636 | 3/20 | 0.64 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.64 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.64 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.64 |
| ▸ | MLNR | O43193 | 1/20 | 0.64 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.64 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.64 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.64 |
| ▸ | APP | P05067 | 1/20 | 0.64 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.64 |
| ▸ | HTR1A | P08908 | 1/20 | 0.64 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13043810 | 0.90 | ADRB2 (0.69) | ADRB2DNM1TLR4DRD2KMT2A | |
| SCHEMBL8295862 | 0.89 | ADRB2 (0.67) | ADRB2DNM1TLR4DRD2KMT2A | |
| SCHEMBL7269307 | 0.88 | ADRB2 (0.66) | ADRB2DNM1TLR4DRD2KMT2A | |
| SCHEMBL11339462 | 0.87 | ADRB2 (0.65) | ADRB2DNM1TLR4DRD2KMT2A | |
| SCHEMBL3002063 | 0.86 | ADRB2 (0.78) | ADRB2DNM1TLR4DRD2KMT2A | |
| SCHEMBL9258048 | 0.86 | ADRB2 (0.64) | ADRB2DNM1TLR4DRD2KMT2A | |
| Carazolol SCHEMBL77901 | 0.84 | ADRB2 (1.00) | ADRB2DNM1TLR4DRD2KMT2A | |
| Carazolol SCHEMBL6511163 | 0.84 | ADRB2 (1.00) | ADRB2DNM1TLR4DRD2KMT2A | |
| Carazolol SCHEMBL29354289 | 0.84 | ADRB2 (1.00) | ADRB2DNM1TLR4DRD2KMT2A | |
| Carazolol SCHEMBL77903 | 0.84 | ADRB2 (1.00) | ADRB2DNM1TLR4DRD2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021552-A9 | BIASED LIGANDS AND METHODS OF IDENTIFYING SAME | UNIV DUKE (US) | 2008-05-29 | — | — | WO | claimed |
| WO-2008021552-A2 | BIASED LIGANDS AND METHODS OF IDENTIFYING SAME | DUKE UNIVERSITY (US) | 2008-02-21 | — | — | WO | claimed |