Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 7/20 | 0.66 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.66 |
| ▸ | TLR4 | O00206 | 6/20 | 0.61 |
| ▸ | ADRB3 | P13945 | 5/20 | 0.61 |
| ▸ | ADRB1 | P08588 | 4/20 | 0.61 |
| ▸ | DRD2 | P14416 | 3/20 | 0.61 |
| ▸ | MAPT | P10636 | 3/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.61 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.61 |
| ▸ | MLNR | O43193 | 1/20 | 0.61 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.61 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.61 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.61 |
| ▸ | APP | P05067 | 1/20 | 0.61 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.61 |
| ▸ | HTR1A | P08908 | 1/20 | 0.61 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.61 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13043810 | 0.89 | ADRB2 (0.69) | ADRB2DNM1TLR4ADRB3ADRB1 | |
| SCHEMBL8295862 | 0.88 | ADRB2 (0.67) | ADRB2DNM1TLR4ADRB3ADRB1 | |
| SCHEMBL4727258 | 0.88 | ADRB2 (0.73) | ADRB2DNM1TLR4ADRB3ADRB1 | |
| SCHEMBL3002063 | 0.86 | ADRB2 (0.78) | ADRB2DNM1TLR4ADRB3ADRB1 | |
| SCHEMBL11339462 | 0.86 | ADRB2 (0.65) | ADRB2DNM1TLR4ADRB3ADRB1 | |
| SCHEMBL8295861 | 0.85 | ADRB2 (0.61) | ADRB2DNM1TLR4ADRB3ADRB1 | |
| SCHEMBL9258048 | 0.83 | ADRB2 (0.64) | ADRB2DNM1TLR4ADRB3ADRB1 | |
| SCHEMBL7274432 | 0.82 | CYP2D6 (0.64) | ADRB2ADRB3ADRB1MAPTKDM4E | |
| SCHEMBL14359316 | 0.80 | ADRB3 (0.75) | ADRB2DNM1TLR4ADRB3ADRB1 | |
| Carazolol SCHEMBL77901 | 0.80 | ADRB2 (1.00) | ADRB2DNM1TLR4ADRB3ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5468746-A | A dicarboxy-4-aryldihydropyridine | ZAMBON GROUP S.P.A. (IT) | 1995-11-21 | — | — | US | disclosed |
| EP-0352863-A2 | 1,4-Dihydropyridine dicarboxylic acid derivatives | ZAMBON GROUP S.p.A. (IT) | 1990-01-31 | — | — | EP | disclosed |