Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 18/20 | 0.51 |
| ▸ | DRD2 | P14416 | 15/20 | 0.51 |
| ▸ | HTR2A | P28223 | 14/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 2/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.41 |
| ▸ | HTR1B | P28222 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4727286 | 0.82 | DRD2 (0.54) | HTR1ADRD2HTR2ASLC6A4 | |
| SCHEMBL4729394 | 0.81 | HTR1A (0.52) | HTR1ADRD2HTR2ASLC6A4HTR1B | |
| SCHEMBL4727139 | 0.80 | DRD2 (0.47) | HTR1ADRD2HTR2ASLC6A4ADRA1D | |
| SCHEMBL4729236 | 0.80 | DRD2 (0.52) | HTR1ADRD2HTR2ASLC6A4HTR7 | |
| SCHEMBL4728053 | 0.79 | HTR1A (0.52) | HTR1ADRD2HTR2ASLC6A4HTR1B | |
| SCHEMBL4728870 | 0.79 | DRD2 (0.51) | HTR1ADRD2HTR2ASLC6A4HTR7 | |
| SCHEMBL4725799 | 0.70 | DRD2 (0.68) | HTR1ADRD2HTR2ASLC6A4 | |
| SCHEMBL4728141 | 0.69 | DRD2 (0.68) | HTR1ADRD2HTR2ASLC6A4 | |
| SCHEMBL4730198 | 0.69 | DRD2 (0.70) | HTR1ADRD2HTR2ASLC6A4 | |
| SCHEMBL20511890 | 0.68 | DRD2 (0.76) | HTR1ADRD2HTR2ASLC6A4HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008020306-A2 | ISOINDOLE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 2008-02-21 | — | — | WO | claimed |