Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.65 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.47 |
| ▸ | TPMT | P51580 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | FYN | P06241 | 1/20 | 0.46 |
| ▸ | RXRA | P19793 | 2/20 | 0.40 |
| ▸ | RARG | P13631 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | RXRB | P28702 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4725566 | 0.85 | HSD17B10 (0.46) | HSD17B10TPMTRXRARARGPPARG | |
| SCHEMBL7786427 | 0.83 | RXRB (0.49) | HSD17B10RXRARARGPPARGHPGD | |
| SCHEMBL5665923 | 0.81 | RXRA (0.56) | HSD17B10RXRARARGPPARGAKR1C3 | |
| SCHEMBL9187455 | 0.81 | RXRB (0.47) | HSD17B10RXRARARGPPARGHPGD | |
| SCHEMBL9192206 | 0.80 | RXRA (0.55) | HSD17B10RXRARARGPPARGAKR1C3 | |
| SCHEMBL1600588 | 0.80 | HSD17B10 (0.44) | HSD17B10RXRARARGPPARGHPGD | |
| SCHEMBL1054399 | 0.80 | CA2 (0.48) | HSD17B10TPMTHPGDALDH1A1TDP1 | |
| SCHEMBL7813490 | 0.79 | HSD17B10 (1.00) | HSD17B10GPR35TPMTLCKFYN | |
| SCHEMBL5243236 | 0.79 | HSD17B10 (0.73) | HSD17B10GPR35TPMTLCKFYN | |
| SCHEMBL10231144 | 0.79 | AKR1C3 (0.45) | HSD17B10RXRARARGPPARGHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008089034-A2 | CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2008-07-24 | — | — | WO | disclosed |
| WO-2008021388-A1 | HETEROARYL DERIVATIVES AS CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2008-02-21 | — | — | WO | disclosed |
| WO-2007075896-A2 | HETEROCYCLIC CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-07-05 | — | — | WO | disclosed |
| WO-2007056016-A2 | BISAMIDE CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-05-18 | — | — | WO | disclosed |