Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 5/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4730966 | 0.88 | ADRA1D (0.47) | ADRA1DADRA1AADRA1B | |
| SCHEMBL4727421 | 0.86 | ADRA1D (0.45) | ADRA1DADRA1AADRA1BHTR1A | |
| SCHEMBL4729818 | 0.86 | ADRA1D (0.46) | ADRA1DADRA1A | |
| SCHEMBL4729947 | 0.85 | ADRA1D (0.45) | ADRA1DADRA1AADRA1BDRD2 | |
| SCHEMBL4733170 | 0.85 | ADRA1D (0.45) | ADRA1DADRA1A | |
| SCHEMBL4731810 | 0.85 | ADRA1D (0.45) | ADRA1DADRA1AADRA1BDRD2HTR1A | |
| SCHEMBL4731954 | 0.82 | ADRA1D (0.41) | ADRA1DADRA1AADRA1BDRD2 | |
| SCHEMBL4727644 | 0.79 | ADRA1D (0.49) | ADRA1DADRA1ALMNAADRA1BDRD2 | |
| SCHEMBL5806578 | 0.77 | HTR1A (0.56) | ADRA1DADRA1AADRA1BDRD2HTR1A | |
| SCHEMBL14066209 | 0.76 | ADRA1D (0.56) | ADRA1DADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008033513-A1 | ISOXAZOLINE ALPHA 1a/1d ADRENORECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-03-20 | — | — | WO | disclosed |