Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.72 |
| ▸ | CES1 | P23141 | 4/20 | 0.72 |
| ▸ | BCHE | P06276 | 2/20 | 0.72 |
| ▸ | ACHE | P22303 | 2/20 | 0.72 |
| ▸ | APAF1 | O14727 | 2/20 | 0.72 |
| ▸ | TP53 | P04637 | 1/20 | 0.72 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.72 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.72 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.72 |
| ▸ | MAPT | P10636 | 1/20 | 0.72 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.72 |
| ▸ | TSHR | P16473 | 1/20 | 0.72 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.72 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.72 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.72 |
| ▸ | CHRM5 | P08912 | 5/20 | 0.68 |
| ▸ | CES2 | O00748 | 1/20 | 0.63 |
| ▸ | ALDH3A1 | P30838 | 7/20 | 0.59 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.59 |
| ▸ | ALDH2 | P05091 | 3/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29487533 | 0.84 | ALDH1A1 (1.00) | ALDH1A1CES1BCHEACHEAPAF1 | |
| SCHEMBL5426477 | 0.84 | ALDH1A1 (1.00) | ALDH1A1CES1BCHEACHEAPAF1 | |
| SCHEMBL30081910 | 0.84 | ALDH1A1 (1.00) | ALDH1A1CES1BCHEACHEAPAF1 | |
| SCHEMBL30937979 | 0.81 | CHRM5 (1.00) | ALDH1A1CES1BCHEACHEAPAF1 | |
| SCHEMBL4597549 | 0.81 | CHRM5 (1.00) | ALDH1A1CES1BCHEACHEAPAF1 | |
| SCHEMBL18288159 | 0.81 | CES1 (0.90) | ALDH1A1CES1BCHEACHEAPAF1 | |
| SCHEMBL22177086 | 0.81 | ALDH1A1 (0.78) | ALDH1A1CES1BCHEACHEAPAF1 | |
| SCHEMBL4597340 | 0.78 | CHRM5 (0.73) | ALDH1A1CES1BCHEACHEAPAF1 | |
| SCHEMBL3027106 | 0.78 | CES1 (1.00) | ALDH1A1CES1BCHEACHEAPAF1 | |
| SCHEMBL953500 | 0.78 | ALDH1A1 (0.60) | ALDH1A1CES1BCHEACHEAPAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008046083-A2 | USE OF OXINDOLE COMPOUNDS AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2008-04-17 | — | — | WO | disclosed |
| US-20070105820-A1 | Oxindole compounds and their uses as therapeutic agents | XENON PHARMACEUTICALS INC. (CA) | 2007-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070105820-A1 | Oxindole compounds and their uses as therapeutic agents | OPRL1, OPRK1, TRPV1 | ALDH1A1 1136/4885CES1 4183/4885BCHE 3876/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.