Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.60 |
| ▸ | ALDH3A1 | P30838 | 2/20 | 0.60 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.60 |
| ▸ | ALDH2 | P05091 | 2/20 | 0.54 |
| ▸ | CES1 | P23141 | 8/20 | 0.46 |
| ▸ | BCHE | P06276 | 4/20 | 0.46 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.46 |
| ▸ | ACHE | P22303 | 2/20 | 0.46 |
| ▸ | APAF1 | O14727 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | TGM2 | P21980 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL953499 | 1.00 | ALDH1A1 (0.60) | ALDH1A1ALDH3A1RCE1ALDH2CES1 | |
| SCHEMBL950201 | 0.86 | ALDH1A1 (0.69) | ALDH1A1ALDH3A1RCE1ALDH2CES1 | |
| SCHEMBL950200 | 0.86 | ALDH1A1 (0.69) | ALDH1A1ALDH3A1RCE1ALDH2CES1 | |
| SCHEMBL4727488 | 0.78 | ALDH1A1 (0.72) | ALDH1A1ALDH3A1ALDH2CES1BCHE | |
| SCHEMBL16798771 | 0.76 | ALDH1A1 (1.00) | ALDH1A1ALDH3A1RCE1ALDH2CES1 | |
| SCHEMBL16798772 | 0.76 | ALDH1A1 (1.00) | ALDH1A1ALDH3A1RCE1ALDH2CES1 | |
| SCHEMBL3949285 | 0.73 | CHRM5 (0.57) | ALDH1A1ALDH2CHRM5 | |
| SCHEMBL3949287 | 0.73 | CHRM5 (0.57) | ALDH1A1ALDH2CHRM5 | |
| SCHEMBL949825 | 0.73 | AR (0.34) | ALDH1A1ALDH3A1RCE1ALDH2MAPT | |
| SCHEMBL950142 | 0.73 | AR (0.34) | ALDH1A1ALDH3A1RCE1ALDH2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2013215-A2 | NOVEL SPIRO[IMIDAZOLIDINE-4,3'-INDOLE]-2,2',5(1'H)-TRIONES FOR TREATMENT OF CONDITIONS ASSOCIATED WITH VANILLOID RECEPTOR 1 | AstraZeneca AB (SE) | 2009-01-14 | — | — | EP | claimed |
| WO-2007091947-A2 | NOVEL SPIRO[IMIDAZOLIDINE-4,3'-INDOLE]-2,2',5(1'H)-TRIONES FOR TREATMENT OF CONDITIONS ASSOCIATED WITH VANILLOID RECEPTOR 1 | ASTRAZENECA AB (SE) | 2007-08-16 | — | — | WO | claimed |
| US-20070185179-A1 | New compounds | ASTRAZENECA AB (SE) | 2007-08-09 | — | — | US | claimed |
| US-7868181-B2 | Compounds | ASTRAZENECA AB (SE) | 2011-01-11 | — | — | US | disclosed |
| US-20090137650-A1 | New Compounds | LEUNG CARMEN | 2009-05-28 | — | — | US | disclosed |
| EP-2013215-A2 | NOVEL SPIRO[IMIDAZOLIDINE-4,3'-INDOLE]-2,2',5(1'H)-TRIONES FOR TREATMENT OF CONDITIONS ASSOCIATED WITH VANILLOID RECEPTOR 1 | AstraZeneca AB (SE) | 2009-01-14 | — | — | EP | disclosed |
| WO-2007091947-A2 | NOVEL SPIRO[IMIDAZOLIDINE-4,3'-INDOLE]-2,2',5(1'H)-TRIONES FOR TREATMENT OF CONDITIONS ASSOCIATED WITH VANILLOID RECEPTOR 1 | ASTRAZENECA AB (SE) | 2007-08-16 | — | — | WO | disclosed |
| US-20070185179-A1 | New compounds | ASTRAZENECA AB (SE) | 2007-08-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090137650-A1 | New Compounds | CLIC1, AQP1, AVPR2 | ALDH1A1 1551/4885ALDH3A1 2412/4885RCE1 67/4885 |
| US-20070185179-A1 | New compounds | CLIC1, AQP1, AVPR2 | ALDH1A1 1551/4885ALDH3A1 2412/4885RCE1 67/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.