Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.47 |
| ▸ | XPO1 | O14980 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.45 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ERAP1 | Q9NZ08 | 2/20 | 0.43 |
| ▸ | CES2 | O00748 | 1/20 | 0.43 |
| ▸ | RXRA | P19793 | 1/20 | 0.42 |
| ▸ | RXRB | P28702 | 1/20 | 0.42 |
| ▸ | RXRG | P48443 | 1/20 | 0.42 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4726103 | 0.98 | HPGD (0.51) | HPGDHSD17B10ALDH1A1KDM4EMEN1 | |
| SCHEMBL1420480 | 0.97 | HPGD (0.50) | HPGDHSD17B10ALDH1A1KDM4EMEN1 | |
| SCHEMBL12552629 | 0.86 | L3MBTL3 (0.49) | HPGDHSD17B10ALDH1A1KDM4EMEN1 | |
| SCHEMBL20577868 | 0.86 | ADRB1 (0.44) | HPGDHSD17B10ALDH1A1KDM4EMEN1 | |
| SCHEMBL1225981 | 0.86 | KMO (0.56) | ALDH1A1ADRB1XPO1CYP3A4FFAR4 | |
| SCHEMBL502328 | 0.86 | DDR1 (0.49) | ALDH1A1ADRB1XPO1CYP3A4FFAR4 | |
| SCHEMBL12552645 | 0.85 | L3MBTL3 (0.48) | ALDH1A1FFAR4 | |
| SCHEMBL1420647 | 0.85 | L3MBTL3 (0.48) | ALDH1A1XPO1FFAR4 | |
| SCHEMBL20577787 | 0.85 | CSF1R (0.48) | ALDH1A1MEN1KMT2AADRB1XPO1 | |
| Hydrochloric Acid SCHEMBL397746 | 0.85 | DDR1 (0.48) | ALDH1A1ADRB1XPO1CYP3A4FFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008089034-A2 | CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2008-07-24 | — | — | WO | disclosed |
| WO-2008021388-A1 | HETEROARYL DERIVATIVES AS CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2008-02-21 | — | — | WO | disclosed |
| WO-2007075896-A2 | HETEROCYCLIC CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-07-05 | — | — | WO | disclosed |