Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.82 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.82 |
| ▸ | RAB9A | P51151 | 4/20 | 0.82 |
| ▸ | LMNA | P02545 | 4/20 | 0.82 |
| ▸ | POLB | P06746 | 4/20 | 0.82 |
| ▸ | GFER | P55789 | 1/20 | 0.82 |
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.77 |
| ▸ | MAPT | P10636 | 5/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.77 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.66 |
| ▸ | HPGD | P15428 | 6/20 | 0.64 |
| ▸ | TP53 | P04637 | 3/20 | 0.64 |
| ▸ | NPC1 | O15118 | 3/20 | 0.64 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.60 |
| ▸ | PKM | P14618 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | SMO | Q99835 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1494832 | 0.90 | KDM4E (0.83) | KDM4ESMN1; SMN2RAB9ALMNAPOLB | |
| SCHEMBL4781504 | 0.85 | KDM4E (0.77) | KDM4ESMN1; SMN2RAB9ALMNAPOLB | |
| SCHEMBL4726403 | 0.84 | KDM4E (0.76) | KDM4ESMN1; SMN2RAB9ALMNAPOLB | |
| SCHEMBL25878632 | 0.83 | KDM4E (0.74) | KDM4ESMN1; SMN2RAB9ALMNAPOLB | |
| SCHEMBL25312016 | 0.83 | ALDH1A1 (0.81) | KDM4ESMN1; SMN2RAB9ALMNAPOLB | |
| SCHEMBL29484580 | 0.83 | ALDH1A1 (0.81) | KDM4ESMN1; SMN2RAB9ALMNAPOLB | |
| SCHEMBL26604703 | 0.81 | RAB9A (0.65) | KDM4ESMN1; SMN2RAB9ALMNAPOLB | |
| SCHEMBL1494756 | 0.81 | RAB9A (0.79) | KDM4ESMN1; SMN2RAB9ALMNAPOLB | |
| SCHEMBL28933829 | 0.81 | ALDH1A1 (0.78) | KDM4ESMN1; SMN2RAB9ALMNAPOLB | |
| SCHEMBL4727282 | 0.81 | KDM4E (0.77) | KDM4ESMN1; SMN2RAB9ALMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008029152-A2 | TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | SUMMIT CORPORATION PLC (GB) | 2008-03-13 | — | — | WO | disclosed |