Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 6/20 | 0.39 |
| ▸ | BRAF | P15056 | 5/20 | 0.35 |
| ▸ | GSK3A | P49840 | 1/20 | 0.34 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.34 |
| ▸ | MALT1 | Q9UDY8 | 2/20 | 0.33 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.33 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4413445 | 0.82 | LMNA (0.44) | MAPK14BRAFNR1H4 | |
| SCHEMBL4728370 | 0.81 | MAPK14 (0.45) | MAPK14BRAFTRPV1 | |
| SCHEMBL4727823 | 0.79 | MAPK14 (0.45) | MAPK14BRAFTRPV1 | |
| SCHEMBL5489688 | 0.79 | BRAF (0.39) | MAPK14BRAFGSK3A | |
| SCHEMBL4728030 | 0.78 | MAPK14 (0.42) | MAPK14BRAFTRPV1 | |
| SCHEMBL4410752 | 0.78 | NPC1 (0.46) | MAPK14 | |
| SCHEMBL4730324 | 0.78 | MAPK14 (0.42) | MAPK14BRAFTRPV1 | |
| SCHEMBL4729989 | 0.77 | MAPK14 (0.43) | MAPK14BRAFTRPV1 | |
| SCHEMBL4565964 | 0.77 | MAPK14 (0.42) | MAPK14BRAF | |
| SCHEMBL4725981 | 0.77 | MAPK14 (0.42) | MAPK14BRAFTRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021388-A1 | HETEROARYL DERIVATIVES AS CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2008-02-21 | — | — | WO | disclosed |