Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | BRAF | P15056 | 4/20 | 0.43 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5489688 | 0.92 | BRAF (0.39) | LMNAGAATSHRBRAFMAPK14 | |
| SCHEMBL4410752 | 0.89 | NPC1 (0.46) | MAPK14NPC1RAB9AMEN1KMT2A | |
| SCHEMBL4565964 | 0.89 | MAPK14 (0.42) | LMNABRAFMAPK14NPC1RAB9A | |
| SCHEMBL4417279 | 0.87 | MAPT (0.41) | BRAFMAPK14TP53NPC1RAB9A | |
| SCHEMBL4410224 | 0.86 | MAPK14 (0.43) | BRAFMAPK14NPC1RAB9AMEN1 | |
| SCHEMBL14534449 | 0.86 | LMNA (0.46) | LMNAGAATSHRNR3C1TP53 | |
| SCHEMBL4420870 | 0.85 | MRGPRX4 (0.43) | LMNAGAABRAFTP53NPC1 | |
| SCHEMBL4411102 | 0.85 | MAPK14 (0.42) | MAPK14NPC1KDM4E | |
| SCHEMBL4414872 | 0.83 | BRAF (0.49) | LMNAGAATSHRBRAFMAPK14 | |
| SCHEMBL4727971 | 0.82 | MAPK14 (0.39) | BRAFMAPK14NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035005-A2 | THERAPY USING CYTOKINE INHIBITORS | Kemia, INC. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007146712-A2 | THERAPY USING CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-12-21 | — | — | WO | disclosed |
| WO-2007056016-A2 | BISAMIDE CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-05-18 | — | — | WO | disclosed |