Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC10A1 | Q14973 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | JAK2 | O60674 | 3/20 | 0.34 |
| ▸ | JAK1 | P23458 | 3/20 | 0.34 |
| ▸ | TYK2 | P29597 | 3/20 | 0.34 |
| ▸ | JAK3 | P52333 | 3/20 | 0.34 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.34 |
| ▸ | IGF1R | P08069 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | FLT4 | P35916 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | MAP3K8 | P41279 | 1/20 | 0.34 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14670401 | 0.78 | NTRK1 (0.37) | JAK2JAK1TYK2JAK3KCNA5 | |
| SCHEMBL4728068 | 0.78 | CTSA (0.38) | — | |
| SCHEMBL4725583 | 0.78 | CCNT1 (0.41) | USP2LMNATP53MAPTMAPK1 | |
| SCHEMBL4727670 | 0.76 | AURKA (0.38) | ALOX15TSHR | |
| SCHEMBL4727991 | 0.75 | CDK2 (0.45) | PIM1CDK2GSK3BPLK1CSNK2A1 | |
| SCHEMBL27738470 | 0.75 | NTRK1 (0.48) | JAK2JAK3CDK2LMNAMAPT | |
| SCHEMBL4729310 | 0.75 | CCNC (0.37) | KDM4ECDK2LMNAMAPTSMN1; SMN2 | |
| SCHEMBL4729364 | 0.75 | CYP2D6 (0.48) | SLC10A1KDM4EMAPK1TGFBR1TSHR | |
| SCHEMBL4780128 | 0.74 | CCNT1 (0.43) | KDM4ECDK2LMNAMAPTMAPK1 | |
| SCHEMBL4728071 | 0.74 | USP1 (0.46) | KDM4ECDK2TP53MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008024634-A1 | PYRIMDINE COMPOUNDS USEFUL AS KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-02-28 | — | — | WO | disclosed |