Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | MYC | P01106 | 1/20 | 0.45 |
| ▸ | MAX | P61244 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.45 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.44 |
| ▸ | ERN1 | O75460 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | SGK1 | O00141 | 1/20 | 0.42 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4730825 | 0.85 | TDP1 (0.51) | POLBMEN1KMT2AMAPTRAB9A | |
| SCHEMBL4726234 | 0.85 | MAPT (0.46) | POLBMEN1KMT2AMAPTKDM4E | |
| SCHEMBL4727538 | 0.81 | KAT2B (0.49) | MEN1KMT2AMAPTNPC1RAB9A | |
| SCHEMBL14293380 | 0.79 | ALDH1A1 (0.43) | MEN1KMT2AMAPTNPC1RAB9A | |
| SCHEMBL4728311 | 0.79 | ABL1 (0.50) | MEN1KMT2AMAPTKDM4ENPC1 | |
| SCHEMBL14908747 | 0.78 | ALDH1A1 (0.49) | POLBMEN1KMT2AMAPTNPC1 | |
| SCHEMBL2152518 | 0.78 | POLB (0.47) | POLBMEN1KMT2AMAPTKDM4E | |
| SCHEMBL5593284 | 0.76 | OPRK1 (0.51) | POLBMEN1KMT2AMAPTKDM4E | |
| SCHEMBL3021443 | 0.76 | POLB (0.73) | POLBMEN1KMT2AMAPTERN1 | |
| SCHEMBL2130747 | 0.75 | POLB (0.47) | POLBMEN1KMT2AMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021388-A1 | HETEROARYL DERIVATIVES AS CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2008-02-21 | — | — | WO | disclosed |
| WO-2008021388-A1 | HETEROARYL DERIVATIVES AS CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2008-02-21 | — | — | WO | disclosed |