Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.50 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 2/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.45 |
| ▸ | KDR | P35968 | 2/20 | 0.45 |
| ▸ | SGK1 | O00141 | 1/20 | 0.45 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 6/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.44 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL38655748 | 0.82 | MAP2K4 (0.48) | SLC2A1PDGFRBKDRMAPTRAB9A | |
| SCHEMBL4728233 | 0.79 | POLB (0.49) | SLC2A1EGFRSGK1CAMKK2MAPT | |
| SCHEMBL38655190 | 0.78 | PDGFRB (0.44) | SLC2A1EGFRPDGFRBKDRMAPT | |
| SCHEMBL4703194 | 0.78 | MAPT (0.51) | SLC2A1EGFRMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL20733018 | 0.78 | SGK1 (0.44) | SLC2A1EGFRPDGFRBKDRSGK1 | |
| SCHEMBL4728295 | 0.77 | KMT2A (0.50) | ABL1MAPTRAB9ASMN1; SMN2TP53 | |
| SCHEMBL11709594 | 0.77 | PDGFRB (0.56) | SLC2A1EGFRPDGFRBKDRSGK1 | |
| SCHEMBL9939712 | 0.76 | ABL1 (0.66) | ABL1PDGFRBKDR | |
| SCHEMBL2152852 | 0.75 | ALDH1A1 (0.46) | MAPTRAB9ASMN1; SMN2TP53TDP1 | |
| SCHEMBL6102320 | 0.75 | SLC2A1 (0.58) | SLC2A1EGFRMAPTRAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021388-A1 | HETEROARYL DERIVATIVES AS CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2008-02-21 | — | — | WO | disclosed |
| WO-2008021388-A1 | HETEROARYL DERIVATIVES AS CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2008-02-21 | — | — | WO | disclosed |