Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 5/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.51 |
| ▸ | HTR1A | P08908 | 2/20 | 0.45 |
| ▸ | DRD2 | P14416 | 2/20 | 0.45 |
| ▸ | HTR2A | P28223 | 2/20 | 0.45 |
| ▸ | HTR7 | P34969 | 2/20 | 0.45 |
| ▸ | HRH1 | P35367 | 2/20 | 0.45 |
| ▸ | DRD3 | P35462 | 2/20 | 0.45 |
| ▸ | HTR2B | P41595 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.42 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4730009 | 0.87 | EPHX1 (0.55) | SLC6A4SLC6A3SLC6A2HDAC8EPHX1 | |
| SCHEMBL30239684 | 0.84 | DPP4 (0.44) | SLC6A4SLC6A3DRD2DPP8DPP7 | |
| SCHEMBL3191528 | 0.73 | SLC6A4 (0.58) | SLC6A4EPHX1DPP7DPP4 | |
| SCHEMBL17732253 | 0.73 | SIGMAR1 (0.42) | KDM4EMAPK1HTT | |
| SCHEMBL4779114 | 0.73 | SLC6A4 (0.55) | SLC6A4SLC6A3HTR1ADRD2DRD3 | |
| SCHEMBL495855 | 0.72 | HDAC8 (0.50) | HDAC8EPHX1CARM1 | |
| SCHEMBL29724812 | 0.71 | KDM4E (0.47) | SLC6A4SLC6A3HTR1ADRD2HTR2A | |
| Hydrochloric Acid SCHEMBL496040 | 0.71 | HDAC8 (0.51) | HDAC8EPHX1CARM1 | |
| SCHEMBL1529725 | 0.71 | CASP3 (0.57) | SLC6A4SLC6A3HSD17B10TSHR | |
| SCHEMBL1529723 | 0.71 | CASP3 (0.57) | SLC6A4SLC6A3HSD17B10TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008036308-A2 | AMINO-SUBSTITUTED HETEROCYCLES, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-03-27 | — | — | WO | disclosed |