Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.40 |
| ▸ | RET | P07949 | 3/20 | 0.39 |
| ▸ | RAF1 | P04049 | 8/20 | 0.39 |
| ▸ | BRAF | P15056 | 8/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.35 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.35 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4782731 | 0.87 | RAF1 (0.39) | EGFRRAF1BRAFMAPK14ABL1 | |
| SCHEMBL4728030 | 0.86 | MAPK14 (0.42) | RAF1BRAFMAPK14 | |
| SCHEMBL4783359 | 0.82 | MAPK14 (0.35) | RETRAF1BRAFMAPK14NTRK1 | |
| SCHEMBL4725979 | 0.82 | MAPK14 (0.43) | RAF1BRAFMAPK14 | |
| SCHEMBL4725981 | 0.81 | MAPK14 (0.42) | RAF1BRAFMAPK14 | |
| SCHEMBL4801725 | 0.80 | RAF1 (0.45) | RAF1BRAFMAPK14 | |
| SCHEMBL4729144 | 0.80 | MAPK14 (0.41) | RAF1BRAFMAPK14 | |
| SCHEMBL4410227 | 0.80 | MAPK14 (0.38) | EGFRRAF1BRAFMAPK14ABL1 | |
| SCHEMBL4726017 | 0.79 | CCNT1 (0.41) | RETRAF1BRAFMAPK14 | |
| SCHEMBL4730324 | 0.79 | MAPK14 (0.42) | RAF1BRAFMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021388-A1 | HETEROARYL DERIVATIVES AS CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2008-02-21 | — | — | WO | disclosed |