Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 2/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 4/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
| ▸ | BRAF | P15056 | 3/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.32 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.32 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.32 |
| ▸ | WDR5 | P61964 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.31 |
| ▸ | RAF1 | P04049 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4783352 | 0.91 | MAPK14 (0.36) | MAPK14NR1I2METRETBRAF | |
| SCHEMBL4728294 | 0.82 | EGFR (0.40) | MAPK14RETBRAFNTRK1NTRK3 | |
| SCHEMBL4799766 | 0.82 | DDT (0.32) | MAPK14NR1I2BRAFMALT1RAF1 | |
| SCHEMBL4779210 | 0.78 | TEK (0.41) | NR1I2BRAFRAF1 | |
| SCHEMBL4783259 | 0.78 | MAPK14 (0.34) | MAPK14NR1I2BRAFMALT1 | |
| SCHEMBL4781875 | 0.78 | SCN10A (0.34) | MAPK14NR1I2BRAFMALT1RAF1 | |
| SCHEMBL13843781 | 0.77 | APP (0.36) | MAPK14NR1I2BRAF | |
| SCHEMBL4779088 | 0.76 | DDR2 (0.38) | BRAFNTRK1NTRK3NTRK2 | |
| SCHEMBL4780945 | 0.76 | DDT (0.33) | NR1I2KMT2A | |
| SCHEMBL4781726 | 0.76 | MAPK14 (0.41) | MAPK14KMT2AMALT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021388-A1 | HETEROARYL DERIVATIVES AS CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2008-02-21 | — | — | WO | disclosed |