Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.46 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.46 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.46 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | FYN | P06241 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28722185 | 0.85 | CHEK2 (0.59) | KMT2AMAPTDYRK1APTGS2MAPK1 | |
| SCHEMBL14293715 | 0.81 | DRD1 (0.56) | KMT2AMAPTMAPK1TP53TSHR | |
| SCHEMBL17178235 | 0.80 | ALDH1A1 (0.55) | KMT2AMAPTMAPK1TP53HTT | |
| SCHEMBL14923566 | 0.79 | IRAK4 (0.46) | KMT2AMAPTMAPK1TP53TSHR | |
| SCHEMBL24171393 | 0.78 | FYN (0.47) | MAP4K4CHEK2FYNABL1KIT | |
| SCHEMBL11236122 | 0.77 | FYN (0.45) | FYNABL1DRD1 | |
| SCHEMBL4728311 | 0.77 | ABL1 (0.50) | KMT2AMAPTMAPK1TP53NPC1 | |
| SCHEMBL4727538 | 0.74 | KAT2B (0.49) | KMT2AMAPTMAPK1HTTNPC1 | |
| SCHEMBL5904303 | 0.73 | CHEK2 (0.58) | KMT2AMAPTDYRK1AMAPK1TP53 | |
| SCHEMBL415914 | 0.73 | TDP1 (0.58) | KMT2AMAPTDYRK1AMAPK1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021388-A1 | HETEROARYL DERIVATIVES AS CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2008-02-21 | — | — | WO | disclosed |