Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.63 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.63 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.63 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.63 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.63 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.63 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.63 |
| ▸ | ESR1 | P03372 | 2/20 | 0.60 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.60 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.53 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.53 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | BLM | P54132 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19700405 | 0.85 | NR4A1 (0.50) | LMNACYP1A2PTGS1SLC6A2CYP2C19 | |
| SCHEMBL4727589 | 0.83 | ESR1 (0.62) | LMNACYP1A2PTGS1SLC6A2SLC6A3 | |
| SCHEMBL400549 | 0.83 | NPC1 (0.48) | LMNACYP1A2PTGS1SLC6A2CYP2C19 | |
| SCHEMBL10042127 | 0.81 | NPC1 (0.49) | LMNACYP1A2PTGS1SLC6A2CYP2C19 | |
| SCHEMBL3468498 | 0.80 | ESR1 (0.56) | SLC6A2SLC6A3ESR1ESR2PSMB1 | |
| SCHEMBL402574 | 0.80 | RAB9A (0.46) | LMNACYP1A2PTGS1SLC6A2CYP2C19 | |
| SCHEMBL3468471 | 0.79 | ESR1 (0.66) | SLC6A2SLC6A3ESR1ESR2GAA | |
| Monobenzone SCHEMBL8450838 | 0.79 | LMNA (1.00) | LMNACYP1A2PTGS1SLC6A2CYP2C19 | |
| Monobenzone SCHEMBL1903511 | 0.79 | LMNA (1.00) | LMNACYP1A2PTGS1SLC6A2CYP2C19 | |
| Monobenzone SCHEMBL11272996 | 0.79 | LMNA (1.00) | LMNACYP1A2PTGS1SLC6A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008030771-A1 | CYCLIC ALKYLIDENE COMPOUNDS AS SELECTIVE ESTROGEN RECEPTOR MODULATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-03-13 | — | — | WO | disclosed |